Quality assurance of African higher education is at the top of the continent’s development agenda. Prompted by the imperative to enhance the quality of higher education, the African Union (AU) and the European Union came together to support the Harmonisation of African Higher Education Quality Assurance and Accreditation Initiative (HAQAA) sine 2015. One of the achievements of the HAQAA Initiative in its first phase is the development of the African Standards and Guidelines for Quality Assurance (ASG-QA) in higher education institutions and quality assurance agencies. The ASG-QA is a continental tool that addresses all levels of quality assurance (institutions and regulatory) and their important links. The tool is envisaged to engender institutional cultures of quality and enhance the quality of higher education in Africa. This contribution reviews the progress made to identify recent developments, challenges still to be faced, and actions required to implement the ASG-QA fully.